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Measurement Systemの製品一覧

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Small Volume Dissolution and Membrane Permeation Measurement System 'μDISS・μFLUX'

Small Volume Dissolution and Membrane Permeation Measurement System 'μDISS・μFLUX'

It is possible to evaluate elution and membrane permeability simultaneously with a small volume!

*μDISS This is a system that combines the Rainbow and Mini-Bath manufactured by Pion. It uses a 25mL glass vial, allowing for solubility measurements in small volumes. In addition to solubility measurements, it can also be used for salt screening and supersaturation evaluation. *μFLUX This is a system that combines a dedicated H-shaped chamber. By using two probes from the Rainbow, it is possible to evaluate dissolution on the donor side and membrane permeability (absorption) on the acceptor side, separated by an artificial membrane. It allows for the evaluation of the effects of formulations on dissolution and membrane permeability, as well as the impact of meals.

  • Dissolution Tester

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Dissolution and membrane permeation simultaneous measurement system 'Macro/Bio FLUX'

Dissolution and membrane permeation simultaneous measurement system 'Macro/Bio FLUX'

Dissolution and membrane permeability can be evaluated simultaneously in the final dosage form! It is also used for predicting biological equivalence tests!

This is a system that combines the Pion Corporation's Rainbow with the dedicated Macro FLUX (Bio FLUX) module and the corresponding dissolution tester. By using two probes from the Rainbow, it is possible to measure dissolution on the donor side of the dissolution tester's vessel and absorption on the acceptor side of the dedicated chamber. Unlike µFLUX, this system allows testing in the final dosage forms such as tablets and capsules. The difference between MacroFLUX and BioFLUX lies in the testing volume. MacroFLUX uses a 1,000 mL vessel, while BioFLUX aims for testing with a volume closer to that of a living organism, using a 500 mL vessel.

  • Dissolution Tester

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Small Volume Solubility Measurement System 'μDISS'

Small Volume Solubility Measurement System 'μDISS'

It is now possible to measure UV in situ without sampling, enabling solubility measurements with a small volume!

The "μDISS" is a system that combines the Rainbow and Mini-Bath manufactured by Pion. It uses a 25mL glass vial, allowing for solubility measurements with a small volume. Additionally, by using an optional insert, it is also possible to conduct solubility measurements with a minimum of 1mL. Besides solubility measurements, it can also be used for salt screening and supersaturation evaluation. 【Features】 ■ Enables solubility measurements with a small sample ■ Allows for the evaluation of supersaturation duration ■ Supports salt screening *For more details, please refer to the related links or feel free to contact us.

  • Other measurement and measuring equipment

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Automatic Dwell Time Distribution Measurement System "ExtruVis"

Automatic Dwell Time Distribution Measurement System "ExtruVis"

Guide the analysis of recorded measurements and access results in seconds!

"ExtruVis" is a system that automatically measures residence time distribution by connecting a PC with dedicated software installed to a camera. The main tasks before use are alignment and the preparation is very simple. It guides the analysis of recorded measurement values, allowing access to results in just a few seconds. Please feel free to contact us when you need assistance. 【Features】 ■ Simple preparation ■ Effective software *For more details, please refer to the related links or feel free to contact us.

  • Other measurement and measuring equipment

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[Case Study of Membrane Permeability Measurement System] Evaluation of Membrane Permeability Using μFLUX

[Case Study of Membrane Permeability Measurement System] Evaluation of Membrane Permeability Using μFLUX

Explaining the effect of pH modifiers on the membrane permeability of diclofenac!

We would like to introduce a case study on the application of the membrane permeability measurement system "μFLUX." In our previous research, we developed a sustained-release formulation containing an alkalizer, and we attempted to apply this device to evaluate its usefulness in reducing gastric mucosal damage caused by DC. In this study, we only simulated the pH environment, but incorporating other components such as lipids and proteins is expected to lead to a more accurate evaluation. 【Case Overview】 ■ Study - Evaluated the impact of pH fluctuations in the microenvironment caused by the alkalizer on the membrane permeability of the acidic drug DC using μFLUX. ■ Results - It was demonstrated that μFLUX could be a useful tool not only for evaluating drug absorption but also for assessing the risk of side effects caused by drug accumulation in tissues. *For more details, please download the PDF or feel free to contact us.

  • Other measurement and measuring equipment

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